Medical Marijuana and Genetics
Have you ever wondered why the same cannabis strains or products can produce different effects in different people? You may be surprised to learn that genetics play a major role in individual responses to marijuana.
Continue reading to find out exactly how genetics influence marijuana’s impact on your body.
Here’s what you need to know.
Why Does Cannabis Affect People Differently?
In order to understand why cannabis effects can vary from person to person, it’s important to discuss how cannabis acts on the brain and body.
Cannabis compounds, such as CBD and THC, interact with receptors within each person’s endocannabinoid system.
By binding to and activating CB1 and CB2 receptors, cannabinoids can produce certain responses, including sleepiness, feelings of euphoria, hunger, pain reduction, and a number of other therapeutic effects.
How Genetics Influence Marijuana’s Impact on Your Body
Cannabinoid Receptors
DNA-produced proteins are the foundation of CB1 and CB2 receptors in the brain. Accordingly, genetic mutations in DNA not only lead to inherited diseases, they can also impact how our bodies react to cannabis.
In fact, researchers have identified 9 different variations of CB1 receptor proteins, and 4 mutations in CB2 receptor proteins. These differences have the potential to alter sensitivity to molecules like THC.
Genetics Influence Outside of the Endocannabinoid System
Our response to cannabis isn’t just based on how our genetics impact cannabinoid receptors.
For example, a mutation in the Akt gene can also modify cannabis effects and make certain people more susceptible to impaired judgement and slow motor response after using marijuana.
Additionally, variations in liver enzymes can impact how an individual processes and experiences cannabis that has been consumed orally, through edibles or tinctures.
To learn more about effects of genetics and cannabis and which product and consumption method is right for you, please contact or visit Dispensary Works today.
